Formulation and Evaluation of Mouth Dissolving Tablet Rivaroxaban and its Validation

ABSTRACT: The foremost intention of present research was the preparation and assessment mouth dissolving formulation Rivaroxaban its validation. During work, this tablet formulated by straight compression technique means Cros-carmellose sodium Sodium starch glycolate as super-disintegrants (concentration 2, 4, 6%) Avicel 102 a binder. preparations were exposed to different consideration parameters like hardness test, friability disintegration release drug content drug. calibration curve API using solvent phosphate buffer pH 6.8 carried out. All prepared formulations have shown findings within prescribed limit. Due large concentration super disintegrants in F8, time can reach 29±0.06 seconds. In used buffer, calculated at intervals 0, 6, 8, 10, 12 minutes. F8 demonstrates 96.5±0.567 percent medication release. UV spectrophotometric validation performed for quantification bulk. estimated 247nm 6.8. linearity range observed 2–12µg/ml.